Arizona possibly has the worst team in this thing , which makes sense considering their decades of futility and lack of a real home grown star at quarterback. Their secondary would be their best hope and Lane and Williams are both two of the best and the Wilson brothers would both keep Manning , and especially his receivers a little scared to attack them. Manning is too smart for that though , he would attack them with the running game and then when the linebackers and Wilson started creeping closer to the line , Mackey would start getting his production.
Defensively the Colts would have some problems with the Cardinals receivers , who are a great duo in their own right. The problem is that you would have to consistently rely on Plummer to get them the ball in the right situations and not make mistakes and I think the Colts defensive line could get some pressure and force Plummer into doing Plummer things. The Cardinals best shot would be running Anderson behind Dierdorf and Gray and hope Dierdorff maybe rips Marchetti's ear off in a scrum.
Colts - 27
P. Manning - 21/30 , 246 Passing Yards , 2 TD's 1 INT
J. Plummer - 24/35 , 289 Passing Yards , 1 TD , 2 INT
E. James - 21 att. , 109 yards , 1 TD
O. Anderson - 16 att , 71 yards , 1 TD
J. Mackey - 7 rec. , 81 yards , 1 TD
L. Fitzgerald - 11 rec. , 121 yards , 0 TD
B. Sanders - 6 tkls , 1 INT , 1 Sack
A. Williams - 2 tkls , 1 INT